MersV1, Main, Exploration, bibRecord, 001778

Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection.

Identifieur interne : 001778 ( Main/Exploration ); précédent : 001777; suivant : 001779

Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection.

Auteurs : Kayla M. Peck [États-Unis] ; Adam S. Cockrell [États-Unis] ; Boyd L. Yount [États-Unis] ; Trevor Scobey [États-Unis] ; Ralph S. Baric [États-Unis] ; Mark T. Heise [États-Unis]

Source :

Journal of virology [ 1098-5514 ] ; 2015.

RBID : pubmed:25653445

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Coronavirus Infections (prevention & control), Dipeptidyl Peptidase 4 (chemistry), Dipeptidyl Peptidase 4 (genetics), Dipeptidyl Peptidase 4 (metabolism), Fluorescent Antibody Technique, Glycosylation, Mice, Middle East Respiratory Syndrome Coronavirus (metabolism), Models, Molecular, Molecular Sequence Data, Species Specificity, Virus Internalization.
MESH :
- chemical , chemistry : Dipeptidyl Peptidase 4.
- chemical , genetics : Dipeptidyl Peptidase 4.
- chemical , metabolism : Dipeptidyl Peptidase 4.
- metabolism : Middle East Respiratory Syndrome Coronavirus.
- prevention & control : Coronavirus Infections.
- Amino Acid Sequence, Animals, Fluorescent Antibody Technique, Glycosylation, Mice, Models, Molecular, Molecular Sequence Data, Species Specificity, Virus Internalization.

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (DPP4) as an entry receptor. Mouse DPP4 (mDPP4) does not support MERS-CoV entry; however, changes at positions 288 and 330 can confer permissivity. Position 330 changes the charge and glycosylation state of mDPP4. We show that glycosylation is a major factor impacting DPP4 receptor function. These results provide insight into DPP4 species-specific differences impacting MERS-CoV host range and may inform MERS-CoV mouse model development.

DOI: 10.1128/JVI.03445-14
PubMed: 25653445

Affiliations:

Le document en format XML

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<author><name sortKey="Peck, Kayla M" sort="Peck, Kayla M" uniqKey="Peck K" first="Kayla M" last="Peck">Kayla M. Peck</name>
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<term>Dipeptidyl Peptidase 4 (chemistry)</term>
<term>Dipeptidyl Peptidase 4 (genetics)</term>
<term>Dipeptidyl Peptidase 4 (metabolism)</term>
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<term>Dipeptidyl peptidase 4 (génétique)</term>
<term>Dipeptidyl peptidase 4 (métabolisme)</term>
<term>Données de séquences moléculaires</term>
<term>Glycosylation</term>
<term>Infections à coronavirus ()</term>
<term>Modèles moléculaires</term>
<term>Pénétration virale</term>
<term>Souris</term>
<term>Spécificité d'espèce</term>
<term>Séquence d'acides aminés</term>
<term>Technique d'immunofluorescence</term>
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<term>Glycosylation</term>
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<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (DPP4) as an entry receptor. Mouse DPP4 (mDPP4) does not support MERS-CoV entry; however, changes at positions 288 and 330 can confer permissivity. Position 330 changes the charge and glycosylation state of mDPP4. We show that glycosylation is a major factor impacting DPP4 receptor function. These results provide insight into DPP4 species-specific differences impacting MERS-CoV host range and may inform MERS-CoV mouse model development. </div>
</front>
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<name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name>
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<name sortKey="Scobey, Trevor" sort="Scobey, Trevor" uniqKey="Scobey T" first="Trevor" last="Scobey">Trevor Scobey</name>
<name sortKey="Yount, Boyd L" sort="Yount, Boyd L" uniqKey="Yount B" first="Boyd L" last="Yount">Boyd L. Yount</name>
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Serveur d'exploration MERS

Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection.

Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration MERS
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